Version 5.4
Homo sapiens Protein: MCU
Summary
InnateDB Protein IDBP-602982.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MCU
Protein Name mitochondrial calcium uniporter
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000440913
InnateDB Gene IDBG-77995 (MCU)
Protein Structure
UniProt Annotation
Function Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Activity is regulated by MICU1 and MICU2 that stimulate and inhibit MCU activity, respectively. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes. {ECO:0000269PubMed:21685886, ECO:0000269PubMed:21685888, ECO:0000269PubMed:22822213, ECO:0000269PubMed:22829870, ECO:0000269PubMed:22904319, ECO:0000269PubMed:23101630, ECO:0000269PubMed:23178883, ECO:0000269PubMed:24332854, ECO:0000269PubMed:24560927}.
Subcellular Localization Mitochondrion inner membrane {ECO:0000269PubMed:21685886, ECO:0000269PubMed:21685888, ECO:0000269PubMed:24231807}; Multi-pass membrane protein {ECO:0000269PubMed:21685886, ECO:0000269PubMed:21685888, ECO:0000269PubMed:24231807}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0015292 uniporter activity
Biological Process
GO:0006851 mitochondrial calcium ion transport
GO:0019722 calcium-mediated signaling
GO:0032024 positive regulation of insulin secretion
GO:0035786 protein complex oligomerization
GO:0036444 calcium ion import into mitochondrion
GO:0042593 glucose homeostasis
GO:0051561 positive regulation of mitochondrial calcium ion concentration
Cellular Component
GO:0005743 mitochondrial inner membrane
GO:0031305 integral component of mitochondrial inner membrane
GO:0034704 calcium channel complex
GO:1990246 uniplex complex
Protein Structure and Domains
PDB ID
InterPro IPR006769 Coiled-coil domain containing protein 109, C-terminal
PFAM PF04678
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NE86
PhosphoSite PhosphoSite-Q8NE86
TrEMBL
UniProt Splice Variant
Entrez Gene 90550
UniGene Hs.607625
RefSeq NP_001257609
HUGO HGNC:23526
OMIM 614197
CCDS CCDS59219
HPRD 10696
IMGT
EMBL AC016542 AC069548 AK128016 AK315519 BC010682 BC034235 CH471083
GenPept AAH10682 AAH34235 BAG37900 BAG54619 EAW54461

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca