Version 5.4
Homo sapiens Gene: MCU
Summary
InnateDB Gene IDBG-77995.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MCU
Gene Name mitochondrial calcium uniporter
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000156026
Encoded Proteins
IDBP-77997
mitochondrial calcium uniporter
IDBP-77999
mitochondrial calcium uniporter
IDBP-602982
mitochondrial calcium uniporter
IDBP-810707
mitochondrial calcium uniporter
IDBP-810711
mitochondrial calcium uniporter
IDBP-810712
mitochondrial calcium uniporter
IDBP-810714
mitochondrial calcium uniporter
IDBP-810715
mitochondrial calcium uniporter
IDBP-810721
mitochondrial calcium uniporter
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a calcium transporter that localizes to the mitochondrial inner membrane. The encoded protein interacts with mitochondrial calcium uptake 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:72692131-72887694
Strand Forward strand
Band q22.1
Transcripts
ENST00000373053 ENSP00000362144
ENST00000357157 ENSP00000349680
ENST00000483185
ENST00000536019 ENSP00000440913
ENST00000603649 ENSP00000474265
ENST00000604372 ENSP00000474820
ENST00000604679 ENSP00000473857
ENST00000605597 ENSP00000473892
ENST00000604152 ENSP00000475141
ENST00000603118
ENST00000605416
ENST00000622066 ENSP00000484991
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0015292 uniporter activity
GO:0042802 identical protein binding
Biological Process
GO:0006851 mitochondrial calcium ion transport
GO:0019722 calcium-mediated signaling
GO:0032024 positive regulation of insulin secretion
GO:0035786 protein complex oligomerization
GO:0036444 calcium ion import into mitochondrion
GO:0042593 glucose homeostasis
GO:0051560 mitochondrial calcium ion homeostasis
GO:0051561 positive regulation of mitochondrial calcium ion concentration
GO:0055085 transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0031305 integral component of mitochondrial inner membrane
GO:0034704 calcium channel complex
GO:1990246 uniplex complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000009647
View Gene Order
ENSBTAG00000003876
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001270679 NM_001270680 NM_138357
HUGO
OMIM
CCDS CCDS59218 CCDS59219 CCDS7317
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca