InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BANF1

Summary

InnateDB Protein

IDBP-602992.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BANF1

Protein Name

barrier to autointegration factor 1

Synonyms

BAF; BCRP1; D14S1460; NGPS;

Species

Homo sapiens

Ensembl Protein

ENSP00000433760

InnateDB Gene

IDBG-58220 (BANF1)

Protein Structure

UniProt Annotation

Function

Plays fundamental roles in nuclear assembly, chromatin organization, gene expression and gonad development. May potently compress chromatin structure and be involved in membrane recruitment and chromatin decondensation during nuclear assembly. Contains 2 non-specific dsDNA-binding sites which may promote DNA cross-bridging. Exploited by retroviruses for inhibiting self- destructing autointegration of retroviral DNA, thereby promoting integration of viral DNA into the host chromosome. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. {ECO:0000269PubMed:11005805, ECO:0000269PubMed:12163470, ECO:0000269PubMed:16680152}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:16495336}. Cytoplasm {ECO:0000269PubMed:16495336}. Chromosome {ECO:0000269PubMed:16495336}. Note=Significantly enriched at the nuclear inner membrane, diffusely throughout the nucleus during interphase and concentrated at the chromosomes during the M-phase. May be included in HIV-1 virions via its interaction with viral GAG polyprotein. The phosphorylated form (by VRK1) shows a cytoplasmic localization.

Disease Associations

Nestor-Guillermo progeria syndrome (NGPS) [MIM:614008]: An atypical progeroid syndrome characterized by normal development in the first years of life, later followed by the emergence of generalized lipoatrophy, severe osteoporosis, and marked osteolysis. The atrophic facial subcutaneous fat pad and the marked osteolysis of the maxilla and mandible result in a typical pseudosenile facial appearance with micrognathia, prominent subcutaneous venous patterning, a convex nasal ridge, and proptosis. Cognitive development is completely normal. Patients do not have cardiovascular dysfunction, atherosclerosis, or metabolic anomalies. {ECO:0000269PubMed:21549337}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Widely expressed. Expressed in colon, brain, heart, kidney, liver, lung, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine, spleen and testis. Not detected in thymus and peripheral blood leukocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 64 experimentally validated interaction(s) in this database.

Experimentally validated
Total	64 [view]
Protein-Protein	64 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0007077	mitotic nuclear envelope disassembly
GO:0007084	mitotic nuclear envelope reassembly
GO:0009615	response to virus
GO:0016032	viral process
GO:0075713	establishment of integrated proviral latency