InnateDB Protein
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IDBP-603048.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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FAIM2
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Protein Name
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Fas apoptotic inhibitory molecule 2
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Synonyms
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LFG; LFG2; NGP35; NMP35; TMBIM2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000449711
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InnateDB Gene
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IDBG-32034 (FAIM2)
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Protein Structure
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Function |
Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development. {ECO:0000269PubMed:10535980, ECO:0000269PubMed:17635665}.
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Subcellular Localization |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Membrane raft {ECO:0000269PubMed:17635665}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in breast carcinoma tissues. Enhanced expression correlates with the grade of the tumor (grade II/grade III) in primary breast tumors (at protein level). Widely expressed. Expressed at high levels in the brain especially in the hippocampus. {ECO:0000269PubMed:10535980, ECO:0000269PubMed:20336406}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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PDB ID |
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InterPro |
IPR006214
Bax inhibitor 1-related
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PFAM |
PF01027
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
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PhosphoSite |
PhosphoSite-Q9BWQ8
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TrEMBL |
F8VV65
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UniProt Splice Variant |
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Entrez Gene |
23017
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UniGene |
Hs.567424
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RefSeq |
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HUGO |
HGNC:17067
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OMIM |
604306
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CCDS |
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HPRD |
09184
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IMGT |
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EMBL |
AC131157
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GenPept |
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