Version 5.4
Homo sapiens Protein: MCF2
Summary
InnateDB Protein IDBP-603089.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MCF2
Protein Name MCF.2 cell line derived transforming sequence
Synonyms ARHGEF21; DBL;
Species Homo sapiens
Ensembl Protein ENSP00000438155
InnateDB Gene IDBG-87861 (MCF2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
Biological Process
GO:0007264 small GTPase mediated signal transduction
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0043065 positive regulation of apoptotic process
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000219 Dbl homology (DH) domain
IPR001849 Pleckstrin homology domain
IPR018159 Spectrin/alpha-actinin
PFAM PF00621
PF00169
PRINTS
PIRSF
SMART SM00325
SM00233
SM00150
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P10911
PhosphoSite PhosphoSite-P10911
TrEMBL
UniProt Splice Variant
Entrez Gene 4168
UniGene Hs.387262
RefSeq NP_001165348
HUGO HGNC:6940
OMIM 311030
CCDS CCDS55514
HPRD 02406
IMGT
EMBL AB085901 AB085902 AK296488 AK302957 AK316416 AL033403 AL117234 AL161777 CH471150 J03639 X12556 X13230
GenPept AAA52172 BAC41200 BAC41201 BAH12371 BAH13855 BAH14787 CAA21955 CAA31069 CAA31617 CAB55301 CAI42107 CAI42108 EAW88427 EAW88430

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca