Version 5.4
Homo sapiens Gene: MCF2
Summary
InnateDB Gene IDBG-87861.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MCF2
Gene Name MCF.2 cell line derived transforming sequence
Synonyms ARHGEF21; DBL
Species Homo sapiens
Ensembl Gene ENSG00000101977
Encoded Proteins
IDBP-87865
MCF.2 cell line derived transforming sequence
IDBP-87867
MCF.2 cell line derived transforming sequence
IDBP-87869
MCF.2 cell line derived transforming sequence
IDBP-381898
MCF.2 cell line derived transforming sequence
IDBP-381901
MCF.2 cell line derived transforming sequence
IDBP-381903
MCF.2 cell line derived transforming sequence
IDBP-480600
MCF.2 cell line derived transforming sequence
IDBP-476150
MCF.2 cell line derived transforming sequence
IDBP-603089
MCF.2 cell line derived transforming sequence
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The oncogenic protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that exerts control over some members of the Rho family of small GTPases. Several transcript variants encoding different isoforms have been found for this gene. These isoforms exhibit different expression patterns and varying levels of GEF activity.[provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:139581770-139708227
Strand Reverse strand
Band q27.1
Transcripts
ENST00000370576 ENSP00000359608
ENST00000370573 ENSP00000359605
ENST00000338585 ENSP00000342204
ENST00000414978 ENSP00000397055
ENST00000437564 ENSP00000403271
ENST00000446225 ENSP00000405848
ENST00000520602 ENSP00000427745
ENST00000519895 ENSP00000430276
ENST00000483690
ENST00000536274 ENSP00000438155
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
Biological Process
GO:0007264 small GTPase mediated signal transduction
GO:0016358 dendrite development
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0043065 positive regulation of apoptotic process
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031139
View Gene Order
ENSBTAG00000004007
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_13638
NRAGE signals death through JNK pathway
REACT_18407
G alpha (12/13) signalling events pathway
REACT_11051
Rho GTPase cycle pathway
REACT_11061
Signalling by NGF pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_14797
Signaling by GPCR pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_13720
Cell death signalling via NRAGE, NRIF and NADE pathway
KEGG
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
rac1_reg_pathway
Regulation of RAC1 activity
rhoa_reg_pathway
Regulation of RhoA activity
cdc42_reg_pathway
Regulation of CDC42 activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.387262
RefSeq NM_001099855 NM_001171876 NM_001171877 NM_001171878 NM_001171879 NM_005369 XM_005262413
HUGO
OMIM
CCDS CCDS14667 CCDS48175 CCDS55514 CCDS55515 CCDS55516 CCDS55517
HPRD 02406
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca