InnateDB Protein
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IDBP-60323.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PXN
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Protein Name
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paxillin
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000267257
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InnateDB Gene
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IDBG-60317 (PXN)
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Protein Structure
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Function |
Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).
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Subcellular Localization |
Cytoplasm, cytoskeleton {ECO:0000269PubMed:20489202}. Cell junction, focal adhesion {ECO:0000269PubMed:20489202}. Cytoplasm, cell cortex {ECO:0000250}. Note=Colocalizes with integrins at the cell periphery. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 236 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated |
Total |
236
[view]
|
Protein-Protein |
236
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
23 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001781
Zinc finger, LIM-type
IPR001904
Paxillin
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PFAM |
PF00412
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PRINTS |
PR00832
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PIRSF |
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SMART |
SM00132
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TIGRFAMs |
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Modification |
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SwissProt |
P49023
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PhosphoSite |
PhosphoSite-P49023
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TrEMBL |
F8W1E0
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UniProt Splice Variant |
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Entrez Gene |
5829
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UniGene |
Hs.446336
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RefSeq |
NP_001230685
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HUGO |
HGNC:9718
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OMIM |
602505
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CCDS |
CCDS58281
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HPRD |
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IMGT |
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EMBL |
AC004263
AK314204
BC136787
BC136794
BC144410
BX648777
D86862
D86863
U14588
U87941
U87942
U87943
U87944
U87945
U87946
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GenPept |
AAC05175
AAC50104
AAD00648
AAI36788
AAI36795
AAI44411
BAA18997
BAA18998
BAG36880
CAI46024
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