InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PXN

Summary

InnateDB Gene

IDBG-60317.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PXN

Gene Name

paxillin

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000089159

Encoded Proteins

IDBP-60319

paxillin

IDBP-60323

paxillin

IDBP-384132

paxillin

IDBP-384133

paxillin

IDBP-599799

paxillin

IDBP-592998

paxillin

IDBP-588854

paxillin

IDBP-598120

paxillin

IDBP-592657

paxillin

IDBP-586474

paxillin

IDBP-584614

paxillin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445). [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:120210439-120265771

Strand

Reverse strand

Band

q24.23

Transcripts

ENST00000228307	ENSP00000228307
ENST00000323871
ENST00000267257	ENSP00000267257
ENST00000424649	ENSP00000391283
ENST00000458477	ENSP00000395536
ENST00000440827
ENST00000536957	ENSP00000443887
ENST00000538144
ENST00000550795	ENSP00000449198
ENST00000547983	ENSP00000446893
ENST00000551327
ENST00000543331	ENSP00000443745
ENST00000546532	ENSP00000447180
ENST00000548912	ENSP00000446607
ENST00000552550	ENSP00000446650
ENST00000547746
ENST00000540221
ENST00000550205
ENST00000547772

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 236 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	236 [view]
Protein-Protein	236 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008270	zinc ion binding
GO:0017166	vinculin binding
GO:0019901	protein kinase binding
GO:0032403	protein complex binding
GO:0051435	BH4 domain binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0006928	cellular component movement
GO:0006936	muscle contraction
GO:0007010	cytoskeleton organization
GO:0007155	cell adhesion
GO:0007160	cell-matrix adhesion
GO:0007165	signal transduction
GO:0007172	signal complex assembly
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007229	integrin-mediated signaling pathway
GO:0008360	regulation of cell shape
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030032	lamellipodium assembly
GO:0034329	cell junction assembly
GO:0034446	substrate adhesion-dependent cell spreading
GO:0034614	cellular response to reactive oxygen species
GO:0045860	positive regulation of protein kinase activity
GO:0048041	focal adhesion assembly
GO:0048754	branching morphogenesis of an epithelial tube
GO:0060396	growth hormone receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005875	microtubule associated complex
GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0005938	cell cortex
GO:0030027	lamellipodium
GO:0031252	cell leading edge