Version 5.4
Homo sapiens Protein: ZNF268
Summary
InnateDB Protein IDBP-603261.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZNF268
Protein Name zinc finger protein 268
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000439539
InnateDB Gene IDBG-66258 (ZNF268)
Protein Structure
UniProt Annotation
Function Isoform 1: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression.Isoform 2: Contributes to cervical carcinogenesis in part through the TNF-alpha-induced NF-kappa-B signaling pathway by interacting with the I-kappa-B-kinase (IKK) core complex.
Subcellular Localization Isoform 1: Nucleus {ECO:0000269PubMed:23665872}.Isoform 2: Nucleus {ECO:0000269PubMed:23665872}. Cytoplasm {ECO:0000269PubMed:23665872}.
Disease Associations
Tissue Specificity Overexpressed in ovarian cancer tissues compared to normal ovarian tissues. Isoform 1 and isoform 2 are expressed in squamous epithelium tissues. Isoform 2 is overexpressed in squamous cervical cancer (at protein level). Expressed in blood cells. Isoform 1 is expressed in pancreas, lung, skeletal muscle, heart, placenta, liver, kidney and brain. Isoform 2 expressed in chronic lymphocytic leukemia (CLL) and several tumor cell lines. Isoform 3 is expressed in several tumor cells. Isoform 5 is expressed in fetal liver and several tumor cells. Isoform 6 is weakly expressed in brain, lung amd small intestin and in several tumor cells. Isoform 7 is expressed in fetal liver and several tumor cells. {ECO:0000269PubMed:12200376, ECO:0000269PubMed:16735226, ECO:0000269PubMed:16865230, ECO:0000269PubMed:18949428, ECO:0000269PubMed:23091055, ECO:0000269PubMed:23946776}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005622 intracellular
Protein Structure and Domains
PDB ID
InterPro IPR001909 Krueppel-associated box
PFAM PF01352
PRINTS
PIRSF
SMART SM00349
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-Q14587
TrEMBL Q9H337
UniProt Splice Variant
Entrez Gene 10795
UniGene Hs.183291
RefSeq NP_694422
HUGO HGNC:13061
OMIM 604753
CCDS CCDS59239
HPRD 05300
IMGT
EMBL AC026786 AC226150 AF141655
GenPept AAG39638

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca