InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLSCR3

Summary

InnateDB Protein

IDBP-603288.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLSCR3

Protein Name

phospholipid scramblase 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000438547

InnateDB Gene

IDBG-24786 (PLSCR3)

Protein Structure

UniProt Annotation

Function

May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Seems to play a role in apoptosis, through translocation of cardiolipin from the inner to the outer mitochondrial membrane which promotes BID recruitment and enhances tBid-induced mitochondrial damages. {ECO:0000269PubMed:17226776}.

Subcellular Localization

Mitochondrion membrane {ECO:0000269PubMed:17226776}; Single-pass type II membrane protein {ECO:0000269PubMed:17226776}.

Disease Associations

Tissue Specificity

Expressed in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine and peripheral blood lymphocytes. Not detected in testis, brain and liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0017124	SH3 domain binding
GO:0017128	phospholipid scramblase activity
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0006915	apoptotic process
GO:0017121	phospholipid scrambling
GO:0042593	glucose homeostasis
GO:0042632	cholesterol homeostasis
GO:0071222	cellular response to lipopolysaccharide