InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CACUL1

Summary

InnateDB Protein

IDBP-603307.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CACUL1

Protein Name

chromosome 10 open reading frame 46

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000431329

InnateDB Gene

IDBG-90944 (CACUL1)

Protein Structure

UniProt Annotation

Function

Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition. {ECO:0000269PubMed:19829063}.

Subcellular Localization

Disease Associations

Tissue Specificity

Ubiquitously expressed with highest expression in the mammary gland and large intestine. Highly expressed in cancer tissues and cancer cell lines. During cell cycle progression expression is high in G1/S, low in the middle of S phase, and increases again in S/G2 phase. {ECO:0000269PubMed:19829063}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0008284	positive regulation of cell proliferation
GO:0045860	positive regulation of protein kinase activity