InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC35B3

Summary

InnateDB Protein

IDBP-60334.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC35B3

Protein Name

solute carrier family 35, member B3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000368981

InnateDB Gene

IDBG-60332 (SLC35B3)

Protein Structure

UniProt Annotation

Function

Mediates the transport of adenosine 3'-phospho 5'- phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. Compensates for the insufficient expression of SLC35B2/PAPST1 during the synthesis of sulfated glycoconjugates in the colon. {ECO:0000269PubMed:16492677}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000269PubMed:16492677}; Multi-pass membrane protein {ECO:0000269PubMed:16492677}.

Disease Associations

Tissue Specificity

Preferentially and highly expressed in colon. {ECO:0000269PubMed:16492677}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006805	xenobiotic metabolic process
GO:0030203	glycosaminoglycan metabolic process
GO:0044281	small molecule metabolic process
GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process
GO:0050428	3'-phosphoadenosine 5'-phosphosulfate biosynthetic process
GO:0055085	transmembrane transport