InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTGS1

Summary

InnateDB Protein

IDBP-603420.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTGS1

Protein Name

prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

Synonyms

COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1; PGHS1; PHS1; PTGHS;

Species

Homo sapiens

Ensembl Protein

ENSP00000437709

InnateDB Gene

IDBG-83887 (PTGS1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004601	peroxidase activity
GO:0004666	prostaglandin-endoperoxide synthase activity
GO:0005515	protein binding
GO:0020037	heme binding
GO:0046872	metal ion binding
GO:0051213	dioxygenase activity

Biological Process

GO:0001516	prostaglandin biosynthetic process
GO:0006629	lipid metabolic process
GO:0006805	xenobiotic metabolic process
GO:0006979	response to oxidative stress
GO:0008217	regulation of blood pressure
GO:0019369	arachidonic acid metabolic process
GO:0019371	cyclooxygenase pathway
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process