InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TMPRSS13

Summary

InnateDB Protein

IDBP-603506.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TMPRSS13

Protein Name

transmembrane protease, serine 13

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000436502

InnateDB Gene

IDBG-73366 (TMPRSS13)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Isoform 1 and isoform 3 are predominantly expressed in lung, placenta, pancreas, and prostate. Isoform 3 is weakly expressed in testis and peripheral blood lymphocytes. {ECO:0000269PubMed:11267681}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005044	scavenger receptor activity
GO:0005515	protein binding
GO:0070008	serine-type exopeptidase activity

Biological Process

GO:0006508	proteolysis
GO:0006898	receptor-mediated endocytosis

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0072562	blood microparticle

Protein Structure and Domains

PDB ID

InterPro

IPR001190 SRCR domain
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR015352 Hepsin, SRCR domain
IPR017448 SRCR-like domain

PFAM

PF00530
PF00089
PF00057
PF09272

PRINTS

PR00258
PR00722
PR00261

PIRSF

SMART

SM00020
SM00192
SM00202

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt