InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TIE1

Summary

InnateDB Protein

IDBP-603654.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TIE1

Protein Name

tyrosine kinase with immunoglobulin-like and EGF-like domains 1

Synonyms

JTK14; TIE;

Species

Homo sapiens

Ensembl Protein

ENSP00000440063

InnateDB Gene

IDBG-97374 (TIE1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0001525	angiogenesis
GO:0007165	signal transduction
GO:0007498	mesoderm development
GO:0018108	peptidyl-tyrosine phosphorylation

Cellular Component

GO:0005887

integral component of plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000742 Epidermal growth factor-like domain

PFAM

PF00008

PRINTS

PIRSF

SMART

SM00181

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P35590

PhosphoSite

PhosphoSite-P35590

TrEMBL

Q6LD63

UniProt Splice Variant

Entrez Gene

7075

UniGene

Hs.78824

RefSeq

HUGO

HGNC:11809

OMIM

600222

CCDS

HPRD

02572

IMGT

EMBL

AC093420 AL139289 BC038239 EU826587 EU826588 S79347 X60957

GenPept

AAD14299 AAH38239 ACF47623 ACF47624 CAA43290