InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CLP1

Summary

InnateDB Protein

IDBP-603687.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLP1

Protein Name

CLP1, cleavage and polyadenylation factor I subunit, homolog (S. cerevisiae)

Synonyms

hClp1; HEAB;

Species

Homo sapiens

Ensembl Protein

ENSP00000433406

InnateDB Gene

IDBG-46990 (CLP1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005524	ATP binding
GO:0046404	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
GO:0051733	polydeoxyribonucleotide kinase activity
GO:0051736	ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006366	transcription from RNA polymerase II promoter
GO:0006369	termination of RNA polymerase II transcription
GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation
GO:0008219	cell death
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0016310	phosphorylation
GO:0021695	cerebellar cortex development
GO:0030423	targeting of mRNA for destruction involved in RNA interference
GO:0031124	mRNA 3'-end processing
GO:0035087	siRNA loading onto RISC involved in RNA interference

Cellular Component

GO:0000214	tRNA-intron endonuclease complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005849	mRNA cleavage factor complex

Protein Structure and Domains

PDB ID

InterPro

IPR010655 Pre-mRNA cleavage complex II Clp1
IPR027417 P-loop containing nucleoside triphosphate hydrolase
IPR029007 MobB-type P-loop domain

PFAM

PF06807
PF03205

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AK300232 AK313007 AP000662 BC000446 CH471076 U73524

GenPept

AAC50780 AAH00446 BAG35843 BAG62000 EAW73770

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca