InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RAP1B

Summary

InnateDB Protein

IDBP-603713.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAP1B

Protein Name

RAP1B, member of RAS oncogene family

Synonyms

K-REV; RAL1B;

Species

Homo sapiens

Ensembl Protein

ENSP00000440014

InnateDB Gene

IDBG-46140 (RAP1B)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	60 [view]
Protein-Protein	60 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019003	GDP binding
GO:0032403	protein complex binding

Biological Process

GO:0006112	energy reserve metabolic process
GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007596	blood coagulation
GO:0015031	protein transport
GO:0030168	platelet activation
GO:0032486	Rap protein signal transduction
GO:0044281	small molecule metabolic process
GO:0050796	regulation of insulin secretion
GO:0061028	establishment of endothelial barrier
GO:0071320	cellular response to cAMP
GO:1901888	regulation of cell junction assembly
GO:2000114	regulation of establishment of cell polarity

Cellular Component

GO:0005622	intracellular
GO:0005811	lipid particle
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001806 Small GTPase superfamily
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00071
PF08477

PRINTS

PR00449

PIRSF

SMART

SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt