Homo sapiens Protein: DOK3
Summary
InnateDB Protein IDBP-60376.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DOK3
Protein Name docking protein 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000349727
InnateDB Gene IDBG-60370 (DOK3)
Protein Structure
UniProt Annotation
Function DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in spleen. {ECO:0000269PubMed:12595900}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005158 insulin receptor binding
GO:0005515 protein binding
Biological Process
GO:0007265 Ras protein signal transduction
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR001849 Pleckstrin homology domain
IPR002404 Insulin receptor substrate-1, PTB
PFAM PF00169
PF02174
PRINTS PR00628
PIRSF
SMART SM00233
SM00310
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7L591
PhosphoSite PhosphoSite-Q7L591
TrEMBL D6RC22
UniProt Splice Variant
Entrez Gene 79930
UniGene Hs.720849
RefSeq NP_079148
HUGO HGNC:24583
OMIM 611435
CCDS CCDS4426
HPRD 16834
IMGT
EMBL AC145098 AK026223 AK097258 BC004564 BC004867 CH471195
GenPept AAH04564 AAH04867 BAB15399 BAC04986 EAW84982 EAW84983