Version 5.4
| Homo sapiens Protein: GPR68 | |||||||
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| Summary | |||||||
| InnateDB Protein | IDBP-604030.3 | ||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
| Gene Symbol | GPR68 | ||||||
| Protein Name | G protein-coupled receptor 68 | ||||||
| Synonyms | GPR12A; OGR1; | ||||||
| Species | Homo sapiens | ||||||
| Ensembl Protein | ENSP00000440797 | ||||||
| InnateDB Gene | IDBG-16259 (GPR68) | ||||||
| Protein Structure |
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| UniProt Annotation | |||||||
| Function | Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer (By similarity). {ECO:0000250}. | ||||||
| Subcellular Localization | Cell membrane; Multi-pass membrane protein. | ||||||
| Disease Associations | |||||||
| Tissue Specificity | Found at low level in a wide range of tissues, but significantly expressed in lung, kidney, bone and nervous system. {ECO:0000269PubMed:12955148}. | ||||||
| Comments | |||||||
| Interactions | |||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||
| PDB ID | |||||||
| InterPro |
IPR000276
G protein-coupled receptor, rhodopsin-like IPR005389 OGR1 sphingosylphosphorylcholine receptor IPR005464 Psychosine receptor IPR017452 GPCR, rhodopsin-like, 7TM IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx |
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| PFAM |
PF00001
PF10320 |
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| PRINTS |
PR00237
PR01564 PR01649 |
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| PIRSF | |||||||
| SMART | |||||||
| TIGRFAMs | |||||||
| Post-translational Modifications | |||||||
| Modification | |||||||
| Cross-References | |||||||
| SwissProt | Q15743 | ||||||
| PhosphoSite | PhosphoSite-Q15743 | ||||||
| TrEMBL | E9PNU7 | ||||||
| UniProt Splice Variant | |||||||
| Entrez Gene | 8111 | ||||||
| UniGene | Hs.8882 | ||||||
| RefSeq | NP_001171147 | ||||||
| HUGO | HGNC:4519 | ||||||
| OMIM | 601404 | ||||||
| CCDS | CCDS9894 | ||||||
| HPRD | 03241 | ||||||
| IMGT | |||||||
| EMBL | AL135818 AY615372 BC067472 BC069592 BC096071 BC096072 BC096073 BC096074 BC098567 CH471061 EU883575 U35398 U48405 | ||||||
| GenPept | AAA79060 AAC50596 AAH67472 AAH69592 AAH96071 AAH96072 AAH96073 AAH96074 AAH98567 AAT38917 ACG60649 EAW81447 EAW81448 | ||||||