InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ISG20

Summary

InnateDB Protein

IDBP-604146.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ISG20

Protein Name

interferon stimulated exonuclease gene 20kDa

Synonyms

CD25; HEM45;

Species

Homo sapiens

Ensembl Protein

ENSP00000453638

InnateDB Gene

IDBG-28713 (ISG20)

Protein Structure

UniProt Annotation

Function

Interferon-induced antiviral exoribonuclease that acts on single-stranded RNA and also has minor activity towards single- stranded DNA. Exhibits antiviral activity against RNA viruses including hepatitis C virus (HCV), hepatitis A virus (HAV) and yellow fever virus (YFV) in an exonuclease-dependent manner. May also play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis. {ECO:0000269PubMed:11401564, ECO:0000269PubMed:12594219, ECO:0000269PubMed:16033969, ECO:0000269PubMed:21036379}.

Subcellular Localization

Nucleus. Nucleus, nucleolus. Cytoplasm. Nucleus, Cajal body.

Disease Associations

Tissue Specificity

Highly expressed in peripheral blood leukocytes, spleen, thymus, colon and lung. Up regulated by E2 in estrogen receptor-positive breast cancer lines. {ECO:0000269PubMed:9235947, ECO:0000269PubMed:9569007}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000175	3'-5'-exoribonuclease activity
GO:0003676	nucleic acid binding
GO:0004527	exonuclease activity
GO:0008310	single-stranded DNA 3'-5' exodeoxyribonuclease activity
GO:0008859	exoribonuclease II activity
GO:0030619	U1 snRNA binding
GO:0030620	U2 snRNA binding
GO:0034511	U3 snoRNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000738	DNA catabolic process, exonucleolytic
GO:0006364	rRNA processing
GO:0006401	RNA catabolic process
GO:0008283	cell proliferation
GO:0009615	response to virus
GO:0019221	cytokine-mediated signaling pathway
GO:0045071	negative regulation of viral genome replication
GO:0045087	innate immune response (InnateDB)
GO:0051607	defense response to virus
GO:0060337	type I interferon signaling pathway
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic