Version 5.4
Homo sapiens Protein: THNSL2
Summary
InnateDB Protein IDBP-60454.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol THNSL2
Protein Name threonine synthase-like 2 (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000366464
InnateDB Gene IDBG-60446 (THNSL2)
Protein Structure
UniProt Annotation
Function Isoform 1: Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho- threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate (By similarity). {ECO:0000250}.Isoform SOLAT: Potent inducer of osteoblastic production of IL6. May act to exacerbate inflammation and/or bone turnover under inflammatory conditions. {ECO:0000269PubMed:19877052}.
Subcellular Localization Isoform SOLAT: Secreted. Note=Secreted by activated T-cells via a calcineurin-independent pathway.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005125 cytokine activity
GO:0016829 lyase activity
GO:0030170 pyridoxal phosphate binding
GO:0070905 serine binding
Biological Process
GO:0008150 biological_process
GO:0009071 serine family amino acid catabolic process
GO:0016311 dephosphorylation
GO:0046360 2-oxobutyrate biosynthetic process
Cellular Component
GO:0005575 cellular_component
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme
PFAM PF00291
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86YJ6
PhosphoSite PhosphoSite-
TrEMBL A8K0C1
UniProt Splice Variant
Entrez Gene 55258
UniGene Hs.740434
RefSeq NP_001231607
HUGO HGNC:25602
OMIM 611261
CCDS CCDS74539
HPRD 07715
IMGT
EMBL AC092836 AK001778 AK095303 AK289486 AK315831 BC035315 BC047758 BC064423 HM185274
GenPept AAH35315 AAH47758 AAH64423 AAX88906 ADL14696 BAA91904 BAF82175 BAF98722 BAG53023

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca