Version 5.4
Homo sapiens Gene: THNSL2
Summary
InnateDB Gene IDBG-60446.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol THNSL2
Gene Name threonine synthase-like 2 (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000144115
Encoded Proteins
IDBP-60448
threonine synthase-like 2 (S. cerevisiae)
IDBP-60452
threonine synthase-like 2 (S. cerevisiae)
IDBP-60454
threonine synthase-like 2 (S. cerevisiae)
IDBP-382321
threonine synthase-like 2 (S. cerevisiae)
IDBP-382324
threonine synthase-like 2 (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a threonine synthase-like protein. A similar enzyme in mouse can catalyze the degradation of O-phospho-homoserine to a-ketobutyrate, phosphate, and ammonia. This protein also has phospho-lyase activity on both gamma and beta phosphorylated substrates. In mouse an alternatively spliced form of this protein has been shown to act as a cytokine and can induce the production of the inflammatory cytokine IL6 in osteoblasts. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:88170295-88186636
Strand Forward strand
Band p11.2
Transcripts
ENST00000343544 ENSP00000339563
ENST00000324166 ENSP00000327323
ENST00000377254 ENSP00000366464
ENST00000449349 ENSP00000407553
ENST00000419759 ENSP00000391300
ENST00000475910
ENST00000496844
ENST00000476349
ENST00000464022
ENST00000496165
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005125 cytokine activity
GO:0016829 lyase activity
GO:0030170 pyridoxal phosphate binding
GO:0070905 serine binding
Biological Process
GO:0008150 biological_process
GO:0009071 serine family amino acid catabolic process
GO:0016311 dephosphorylation
GO:0046360 2-oxobutyrate biosynthetic process
Cellular Component
GO:0005575 cellular_component
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000054474
View Gene Order
ENSBTAG00000004364
Not yet available
Cross-References
SwissProt Q86YJ6
TrEMBL C9J3J1
UniProt Splice Variant
Entrez Gene 55258
UniGene Hs.740434
RefSeq NM_001244676 XM_005264404 XM_006712043 NM_001244678 NM_018271 XM_005264400 XM_005264401 XM_005264402 XM_006712042 XM_006712044
HUGO HGNC:25602
OMIM 611261
CCDS CCDS58718 CCDS2002 CCDS74539
HPRD 07715
IMGT
EMBL AC092836 AK001778 AK095303 BC035315 BC047758 BC064423 HM185274
GenPept AAH35315 AAH47758 AAH64423 AAX88906 ADL14696 BAA91904 BAG53023
RNA Seq Atlas 55258

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca