InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SRSF9

Summary

InnateDB Protein

IDBP-60614.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SRSF9

Protein Name

serine/arginine-rich splicing factor 9

Synonyms

SFRS9; SRp30c;

Species

Homo sapiens

Ensembl Protein

ENSP00000229390

InnateDB Gene

IDBG-60612 (SRSF9)

Protein Structure

UniProt Annotation

Function

Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269PubMed:10196175, ECO:0000269PubMed:11875052, ECO:0000269PubMed:12024014, ECO:0000269PubMed:12604611, ECO:0000269PubMed:15009090, ECO:0000269PubMed:15009664, ECO:0000269PubMed:15695522, ECO:0000269PubMed:7556075}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:10196175, ECO:0000269PubMed:11694584, ECO:0000269PubMed:12024014, ECO:0000269PubMed:12604611}. Note=Cellular stresses such as heat shock may induce localization to discrete nuclear bodies termed SAM68 nuclear bodies (SNBs), HAP bodies, or stress bodies. Numerous splicing factors including SRSF1/SFRS1/SF2, SRSF7/SFRS7, SAFB and KHDRBS1/SAM68 accumulate at these structures, which may participate in the post-transcriptional regulation of mRNAs in stressed cells.

Disease Associations

Tissue Specificity

Expressed at high levels in the heart, kidney, pancreas and placenta, and at lower levels in the brain, liver, lung and skeletal muscle. {ECO:0000269PubMed:10196175}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.

Experimentally validated
Total	66 [view]
Protein-Protein	65 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006366	transcription from RNA polymerase II promoter
GO:0006369	termination of RNA polymerase II transcription
GO:0006376	mRNA splice site selection
GO:0006397	mRNA processing
GO:0006406	mRNA export from nucleus
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0031124	mRNA 3'-end processing
GO:0048025	negative regulation of mRNA splicing, via spliceosome