InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SRSF9

Summary

InnateDB Gene

IDBG-60612.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SRSF9

Gene Name

serine/arginine-rich splicing factor 9

Synonyms

SFRS9; SRp30c

Species

Homo sapiens

Ensembl Gene

ENSG00000111786

Encoded Proteins

IDBP-60614

serine/arginine-rich splicing factor 9

IDBP-585543

serine/arginine-rich splicing factor 9

IDBP-808778

serine/arginine-rich splicing factor 9

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two pseudogenes, one on chromosome 15 and the other on chromosome 21, have been found for this gene. [provided by RefSeq, Sep 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:120461668-120469793

Strand

Reverse strand

Band

q24.31

Transcripts

ENST00000229390	ENSP00000229390
ENST00000548326
ENST00000548792
ENST00000550458	ENSP00000449030
ENST00000546942
ENST00000603963	ENSP00000474283

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.

Experimentally validated
Total	66 [view]
Protein-Protein	65 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006366	transcription from RNA polymerase II promoter
GO:0006369	termination of RNA polymerase II transcription
GO:0006376	mRNA splice site selection
GO:0006397	mRNA processing
GO:0006406	mRNA export from nucleus
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0031124	mRNA 3'-end processing
GO:0048025	negative regulation of mRNA splicing, via spliceosome