InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PROP1

Summary

InnateDB Protein

IDBP-60640.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PROP1

Protein Name

PROP paired-like homeobox 1

Synonyms

CPHD2; PROP-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000311290

InnateDB Gene

IDBG-60638 (PROP1)

Protein Structure

UniProt Annotation

Function

Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108}.

Disease Associations

Pituitary hormone deficiency, combined, 2 (CPHD2) [MIM:262600]: Combined pituitary hormone deficiency is defined as the impaired production of growth hormone and one or more of the other five anterior pituitary hormones. CPHD2 is characterized by pleiotropic deficiencies of growth hormone, thyroid-stimulating hormone, follicle-stimulating hormone, luteinizing hormone, prolactin and adrenocorticotropic hormone. {ECO:0000269PubMed:10946881, ECO:0000269PubMed:11549703, ECO:0000269PubMed:12519826, ECO:0000269PubMed:15531542, ECO:0000269PubMed:19128366, ECO:0000269PubMed:9462743, ECO:0000269PubMed:9768691}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed specifically in embryonic pituitary.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008022	protein C-terminus binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001568	blood vessel development
GO:0007417	central nervous system development
GO:0009887	organ morphogenesis
GO:0009953	dorsal/ventral pattern formation
GO:0016477	cell migration
GO:0021979	hypothalamus cell differentiation
GO:0021984	adenohypophysis development
GO:0043066	negative regulation of apoptotic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048732	gland development
GO:0048850	hypophysis morphogenesis
GO:0060070	canonical Wnt signaling pathway
GO:0060126	somatotropin secreting cell differentiation