Version 5.4
Homo sapiens Protein: SPHK2
Summary
InnateDB Protein IDBP-60760.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPHK2
Protein Name sphingosine kinase 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000245222
InnateDB Gene IDBG-60754 (SPHK2)
Protein Structure
UniProt Annotation
Function Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro- dihydrosphingosine, D-erythro-sphingosine and L-threo- dihydrosphingosine. Binds phosphoinositides. {ECO:0000269PubMed:19168031}.
Subcellular Localization Isoform 1: Cytoplasm. Membrane.Isoform 2: Lysosome membrane.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003951 NAD+ kinase activity
GO:0004143 diacylglycerol kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008481 sphinganine kinase activity
GO:0017016 Ras GTPase binding
GO:0017050 D-erythro-sphingosine kinase activity
Biological Process
GO:0001568 blood vessel development
GO:0006665 sphingolipid metabolic process
GO:0006669 sphinganine-1-phosphate biosynthetic process
GO:0006670 sphingosine metabolic process
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007420 brain development
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0016310 phosphorylation
GO:0030148 sphingolipid biosynthetic process
GO:0043066 negative regulation of apoptotic process
GO:0044281 small molecule metabolic process
GO:0046834 lipid phosphorylation
Cellular Component
GO:0005765 lysosomal membrane
GO:0005829 cytosol
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR001206 Diacylglycerol kinase, catalytic domain
PFAM PF00781
PRINTS
PIRSF
SMART SM00046
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NRA0
PhosphoSite PhosphoSite-Q9NRA0
TrEMBL Q8N2M3
UniProt Splice Variant
Entrez Gene 56848
UniGene Hs.743117
RefSeq NP_064511
HUGO HGNC:18859
OMIM 607092
CCDS CCDS12727
HPRD 06157
IMGT
EMBL AC022154 AF245447 AK000599 AK074601 AK300541 AL136701 BC006161 BC010671 CH471177 EF107108
GenPept AAF74124 AAH06161 AAH10671 ABK81123 BAA91280 BAC11085 BAG62249 CAB66636 EAW52367 EAW52369 EAW52370

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca