InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SPHK2

Summary

InnateDB Gene

IDBG-60754.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPHK2

Gene Name

sphingosine kinase 2

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000063176

Encoded Proteins

IDBP-60758

sphingosine kinase 2

IDBP-60760

sphingosine kinase 2

IDBP-382808

sphingosine kinase 2

IDBP-765178

IDBP-765318

IDBP-765898

IDBP-761064

IDBP-763447

IDBP-765877

IDBP-763845

IDBP-764215

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:48619291-48630717

Strand

Forward strand

Band

q13.33

Transcripts

ENST00000340932	ENSP00000341091
ENST00000245222	ENSP00000245222
ENST00000426514	ENSP00000410044
ENST00000599029	ENSP00000472983
ENST00000601712	ENSP00000471180
ENST00000600537	ENSP00000470092
ENST00000598574
ENST00000597434	ENSP00000471111
ENST00000601704	ENSP00000469448
ENST00000599748	ENSP00000471205
ENST00000598088	ENSP00000469158
ENST00000599033
ENST00000593308	ENSP00000470679

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003951	NAD+ kinase activity
GO:0004143	diacylglycerol kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008481	sphinganine kinase activity
GO:0017016	Ras GTPase binding
GO:0017050	D-erythro-sphingosine kinase activity

Biological Process

GO:0001568	blood vessel development
GO:0006665	sphingolipid metabolic process
GO:0006669	sphinganine-1-phosphate biosynthetic process
GO:0006670	sphingosine metabolic process
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007420	brain development
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0016310	phosphorylation
GO:0030148	sphingolipid biosynthetic process
GO:0043066	negative regulation of apoptotic process
GO:0044281	small molecule metabolic process
GO:0046834	lipid phosphorylation

Cellular Component

GO:0005765	lysosomal membrane
GO:0005829	cytosol
GO:0016020	membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000057342

View Gene Order

ENSBTAG00000009872

Not yet available

Pathways

NETPATH

REACTOME

REACT_115810

Sphingolipid de novo biosynthesis pathway

REACT_19323

Sphingolipid metabolism pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_111217

Metabolism pathway

KEGG

hsa04370

VEGF signaling pathway pathway

hsa00600

Sphingolipid metabolism pathway

hsa04020

Calcium signaling pathway pathway

hsa04666

Fc gamma R-mediated phagocytosis pathway

INOH

PID NCI

ceramide_pathway

Ceramide signaling pathway

il12_2pathway

IL12-mediated signaling events

Cross-References

SwissProt

Q9NRA0

TrEMBL

Q8N2M3

UniProt Splice Variant

Entrez Gene

56848

UniGene

Hs.528006 Hs.743117

RefSeq

NM_001204158 XM_006723293 NM_001204159 NM_001204160 NM_001243876 NM_020126 XM_006723291 XM_006723292 XM_006723294

HUGO

HGNC:18859

OMIM

607092

CCDS

CCDS59404 CCDS12727 CCDS59405 CCDS74414

HPRD

06157

IMGT

EMBL

AC022154 AF245447 AK000599 AK074601 AK300541 AL136701 BC006161 BC010671 EF107108

GenPept

AAF74124 AAH06161 AAH10671 ABK81123 BAA91280 BAC11085 BAG62249 CAB66636

RNA Seq Atlas

56848