InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: WWTR1

Summary

InnateDB Protein

IDBP-60804.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WWTR1

Protein Name

WW domain containing transcription regulator 1

Synonyms

TAZ;

Species

Homo sapiens

Ensembl Protein

ENSP00000353847

InnateDB Gene

IDBG-60802 (WWTR1)

Protein Structure

UniProt Annotation

Function

Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition. {ECO:0000269PubMed:11118213, ECO:0000269PubMed:18227151, ECO:0000269PubMed:18568018, ECO:0000269PubMed:19010321}.

Subcellular Localization

Nucleus. Cytoplasm. Note=Concentrates along specific portions of the plasma membrane, and accumulates in punctate nuclear bodies. When phosphorylated, is retained in cytoplasm by YWHAZ. Can be retained in the nucleus by MED15.

Disease Associations

Tissue Specificity

Highly expressed in kidney, heart, placenta and lung. Expressed in the thyroid tissue. {ECO:0000269PubMed:11118213, ECO:0000269PubMed:19010321}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	28 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0005515	protein binding

Biological Process

GO:0001933	negative regulation of protein phosphorylation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006469	negative regulation of protein kinase activity
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0010467	gene expression
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0017145	stem cell division
GO:0035329	hippo signaling
GO:0035414	negative regulation of catenin import into nucleus
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060390	regulation of SMAD protein import into nucleus
GO:0090090	negative regulation of canonical Wnt signaling pathway