InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CABP1

Summary

InnateDB Protein

IDBP-60882.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CABP1

Protein Name

calcium binding protein 1

Synonyms

CALBRAIN; HCALB_BR;

Species

Homo sapiens

Ensembl Protein

ENSP00000288616

InnateDB Gene

IDBG-60878 (CABP1)

Protein Structure

UniProt Annotation

Function

Modulates calcium-dependent activity of inositol 1,4,5- triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but resulting in an opposit effects on channel function. Suppresses the calcium-dependent inactivation of CACNA1D (By similarity). Inhibits TRPC5 channels. Prevents NMDA receptor- induced cellular degeneration (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=L-CaBP1 is associated most likely with the cytoskeletal structures, whereas S-CaBP1 is localized at or near the plasma membrane.Isoform L-CaBP1: Cytoplasm, cytoskeleton. Note=L-CaBP1 is associated most likely with the cytoskeletal structures.Isoform S-CaBP1: Cytoplasm, cell cortex. Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Note=S- CaBP1 is localized at or near the plasma membrane.

Disease Associations

Tissue Specificity

Retina and brain. Somatodendritic compartment of neurons. Calbrain was found exclusively in brain where it is abundant in the hippocampus, habenular area in the epithalamus and in the cerebellum.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004857	enzyme inhibitor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008139	nuclear localization sequence binding
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0042308	negative regulation of protein import into nucleus
GO:0043086	negative regulation of catalytic activity

Cellular Component

GO:0000139	Golgi membrane
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0005938	cell cortex
GO:0014069	postsynaptic density
GO:0030054	cell junction
GO:0045211	postsynaptic membrane
GO:0048471	perinuclear region of cytoplasm