InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CABP1

Summary

InnateDB Gene

IDBG-60878.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CABP1

Gene Name

calcium binding protein 1

Synonyms

CALBRAIN; HCALB_BR

Species

Homo sapiens

Ensembl Gene

ENSG00000157782

Encoded Proteins

IDBP-60880

calcium binding protein 1

IDBP-60882

calcium binding protein 1

IDBP-60884

calcium binding protein 1

IDBP-384228

calcium binding protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Calcium binding proteins are an important component of calcium mediated cellular signal transduction. This gene encodes a protein that belongs to a subfamily of calcium binding proteins which share similarity to calmodulin. The protein encoded by this gene regulates the gating of voltage-gated calcium ion channels. This protein inhibits calcium-dependent inactivation and supports calcium-dependent facilitation of ion channels containing voltage-dependent L-type calcium channel subunit alpha-1C. This protein also regulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors, P/Q-type voltage-gated calcium channels, and transient receptor potential channel TRPC5. This gene is predominantly expressed in retina and brain. Alternative splicing results in multiple transcript variants encoding disinct isoforms. [provided by RefSeq, Jul 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:120640552-120667324

Strand

Forward strand

Band

q24.31

Transcripts

ENST00000316803	ENSP00000317310
ENST00000288616	ENSP00000288616
ENST00000351200	ENSP00000288615
ENST00000453000	ENSP00000398959
ENST00000498082

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004857	enzyme inhibitor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008139	nuclear localization sequence binding
GO:0019904	protein domain specific binding
GO:0031800	type 3 metabotropic glutamate receptor binding
GO:0042803	protein homodimerization activity
GO:0044325	ion channel binding
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0010651	negative regulation of cell communication by electrical coupling
GO:0042308	negative regulation of protein import into nucleus
GO:0043086	negative regulation of catalytic activity
GO:1901385	regulation of voltage-gated calcium channel activity
GO:1901386	negative regulation of voltage-gated calcium channel activity

Cellular Component

GO:0000139	Golgi membrane
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005938	cell cortex
GO:0009898	cytoplasmic side of plasma membrane
GO:0014069	postsynaptic density
GO:0030054	cell junction
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0043234	protein complex
GO:0045211	postsynaptic membrane
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000029544

View Gene Order

ENSBTAG00000020049

Not yet available

Cross-References

SwissProt

Q9NZU7

TrEMBL

UniProt Splice Variant

Entrez Gene

9478

UniGene

Hs.458482

RefSeq

NM_001033677 NM_004276 NM_031205 XM_005253994

HUGO

HGNC:1384

OMIM

605563

CCDS

CCDS31913 CCDS9204 CCDS9205

HPRD

IMGT

EMBL

AC069234 AF169148 AF169149 BC030201 X94700

GenPept

AAF25782 AAF25783 AAH30201 CAA64361

RNA Seq Atlas

9478