InnateDB Protein
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IDBP-60884.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CABP1
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Protein Name
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calcium binding protein 1
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Synonyms
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CALBRAIN; HCALB_BR;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000288615
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InnateDB Gene
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IDBG-60878 (CABP1)
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Protein Structure
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Function |
Modulates calcium-dependent activity of inositol 1,4,5- triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but resulting in an opposit effects on channel function. Suppresses the calcium-dependent inactivation of CACNA1D (By similarity). Inhibits TRPC5 channels. Prevents NMDA receptor- induced cellular degeneration (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=L-CaBP1 is associated most likely with the cytoskeletal structures, whereas S-CaBP1 is localized at or near the plasma membrane.Isoform L-CaBP1: Cytoplasm, cytoskeleton. Note=L-CaBP1 is associated most likely with the cytoskeletal structures.Isoform S-CaBP1: Cytoplasm, cell cortex. Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Note=S- CaBP1 is localized at or near the plasma membrane.
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Disease Associations |
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Tissue Specificity |
Retina and brain. Somatodendritic compartment of neurons. Calbrain was found exclusively in brain where it is abundant in the hippocampus, habenular area in the epithalamus and in the cerebellum.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
12
[view]
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Protein-Protein |
12
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
GO:0042308
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negative regulation of protein import into nucleus
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GO:0043086
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negative regulation of catalytic activity
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Cellular Component |
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PDB ID |
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InterPro |
IPR002048
EF-hand domain
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PFAM |
PF00036
PF13202
PF13405
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PRINTS |
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PIRSF |
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SMART |
SM00054
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NZU7
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PhosphoSite |
PhosphoSite-Q9NZU7
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
9478
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UniGene |
Hs.458482
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RefSeq |
NP_004267
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HUGO |
HGNC:1384
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OMIM |
605563
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CCDS |
CCDS9204
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HPRD |
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IMGT |
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EMBL |
AC069234
AF169148
AF169149
BC030201
X94700
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GenPept |
AAF25782
AAF25783
AAH30201
CAA64361
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