InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RNF13

Summary

InnateDB Protein

IDBP-60899.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNF13

Protein Name

ring finger protein 13

Synonyms

RZF;

Species

Homo sapiens

Ensembl Protein

ENSP00000341361

InnateDB Gene

IDBG-60897 (RNF13)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation. {ECO:0000269PubMed:18794910}.

Subcellular Localization

Endoplasmic reticulum membrane. Golgi apparatus membrane. Late endosome membrane {ECO:0000250}; Single- pass membrane protein {ECO:0000250}. Lysosome membrane. Nucleus inner membrane {ECO:0000250}. Note=Under certain conditions, relocalizes to recycling endosomes and to the inner nuclear membrane. {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed (at protein level). In normal pancreas, expressed in islets, but not in ducts, nor in acini (at protein level). {ECO:0000269PubMed:18794910}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0051865

protein autoubiquitination

Cellular Component

GO:0000139	Golgi membrane
GO:0005637	nuclear inner membrane
GO:0005765	lysosomal membrane
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0031902	late endosome membrane