InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PROM2

Summary

InnateDB Protein

IDBP-61087.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PROM2

Protein Name

prominin 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000318520

InnateDB Gene

IDBG-61085 (PROM2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Apical cell membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}. Basolateral cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, microvillus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, cilium membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Colocalizes with PROM1. Associates with membrane in a cholesterol-dependent manner. Localizes to the apical and basolateral membranes of epithelial cells (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Present in saliva within small membrane particles (at protein level). Expressed in kidney, prostate, trachea, esophagus, salivary gland, thyroid gland, mammary gland adrenal gland, placenta, stomach, spinal cord and liver. In submucosal tumor, expressed in spindle-shaped or stellate stromal cells. Expressed in prostate cancer cell lines. {ECO:0000269PubMed:12446606, ECO:0000269PubMed:12514187, ECO:0000269PubMed:16673119, ECO:0000269PubMed:17874118}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015485	cholesterol binding

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0031346	positive regulation of cell projection organization
GO:0043088	regulation of Cdc42 GTPase activity
GO:0048550	negative regulation of pinocytosis
GO:2001287	negative regulation of caveolin-mediated endocytosis

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0005902	microvillus
GO:0005929	cilium
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0031410	cytoplasmic vesicle
GO:0031528	microvillus membrane
GO:0042995	cell projection
GO:0044393	microspike
GO:0045121	membrane raft
GO:0060170	ciliary membrane
GO:0070062	extracellular vesicular exosome
GO:0071914	prominosome