Version 5.4
Homo sapiens Gene: PROM2
Summary
InnateDB Gene IDBG-61085.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PROM2
Gene Name prominin 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000155066
Encoded Proteins
IDBP-61087
prominin 2
IDBP-61089
prominin 2
IDBP-295268
prominin 2
IDBP-382622
prominin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the prominin family of pentaspan membrane glycoproteins. The encoded protein localizes to basal epithelial cells and may be involved in the organization of plasma membrane microdomains. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:95274453-95291308
Strand Forward strand
Band q11.1
Transcripts
ENST00000317668 ENSP00000318520
ENST00000317620 ENSP00000318270
ENST00000403131 ENSP00000385716
ENST00000431567 ENSP00000402753
ENST00000487138
ENST00000463580
ENST00000477767
ENST00000478295
ENST00000497110
ENST00000495540
ENST00000462029
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0015485 cholesterol binding
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0031346 positive regulation of cell projection organization
GO:0043088 regulation of Cdc42 GTPase activity
GO:0048550 negative regulation of pinocytosis
GO:2001287 negative regulation of caveolin-mediated endocytosis
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005902 microvillus
GO:0005929 cilium
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0031410 cytoplasmic vesicle
GO:0031528 microvillus membrane
GO:0042995 cell projection
GO:0044393 microspike
GO:0045121 membrane raft
GO:0060170 ciliary membrane
GO:0070062 extracellular vesicular exosome
GO:0071914 prominosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027376
View Gene Order
ENSBTAG00000001952
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.469313 Hs.604290
RefSeq NM_001165977 NM_001165978 NM_144707 XM_005263880 XM_005263881 XM_006712301
HUGO
OMIM
CCDS CCDS2012
HPRD 17912
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca