InnateDB Protein
|
IDBP-61089.7
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
PROM2
|
Protein Name
|
prominin 2
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000318270
|
InnateDB Gene
|
IDBG-61085 (PROM2)
|
Protein Structure
|
|
Function |
|
Subcellular Localization |
Apical cell membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}. Basolateral cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, microvillus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, cilium membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Colocalizes with PROM1. Associates with membrane in a cholesterol-dependent manner. Localizes to the apical and basolateral membranes of epithelial cells (By similarity). {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
Present in saliva within small membrane particles (at protein level). Expressed in kidney, prostate, trachea, esophagus, salivary gland, thyroid gland, mammary gland adrenal gland, placenta, stomach, spinal cord and liver. In submucosal tumor, expressed in spindle-shaped or stellate stromal cells. Expressed in prostate cancer cell lines. {ECO:0000269PubMed:12446606, ECO:0000269PubMed:12514187, ECO:0000269PubMed:16673119, ECO:0000269PubMed:17874118}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
|
Predicted by orthology |
Total |
1 [view]
|
|
|
Molecular Function |
|
Biological Process |
GO:0001934
|
positive regulation of protein phosphorylation
|
GO:0031346
|
positive regulation of cell projection organization
|
GO:0043088
|
regulation of Cdc42 GTPase activity
|
GO:0048550
|
negative regulation of pinocytosis
|
GO:2001287
|
negative regulation of caveolin-mediated endocytosis
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR008795
Prominin
|
PFAM |
PF05478
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q8N271
|
PhosphoSite |
PhosphoSite-Q8N271
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
150696
|
UniGene |
Hs.604290
|
RefSeq |
NP_001159450
|
HUGO |
HGNC:20685
|
OMIM |
|
CCDS |
CCDS2012
|
HPRD |
17912
|
IMGT |
|
EMBL |
AC009238
AF245303
AF245304
AK091175
AK091408
AK290366
AY358377
BC113877
BC114525
CH471219
|
GenPept |
AAI13878
AAI14526
AAM10541
AAM10542
AAQ88743
AAY14751
BAC03599
BAC03657
BAF83055
EAX10718
|
|
|