InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ENTPD6

Summary

InnateDB Protein

IDBP-61156.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ENTPD6

Protein Name

ectonucleoside triphosphate diphosphohydrolase 6 (putative)

Synonyms

CD39L2; dJ738P15.3; IL-6SAG; IL6ST2; NTPDase-6;

Species

Homo sapiens

Ensembl Protein

ENSP00000365840

InnateDB Gene

IDBG-61152 (ENTPD6)

Protein Structure

UniProt Annotation

Function

Might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides. Hydrolyzes preferentially nucleoside 5'-diphosphates, nucleoside 5'-triphosphates are hydrolyzed only to a minor extent, there is no hydrolysis of nucleoside 5'-monophosphates. The order of activity with different substrates is GDP > IDP >> UDP = CDP >> ADP (By similarity). {ECO:0000250}.

Subcellular Localization

Golgi apparatus membrane; Single-pass type II membrane protein. Secreted. Note=But also occurs in a soluble extracellular form.

Disease Associations

Tissue Specificity

Expressed in most tissues, but predominantly in heart. {ECO:0000269PubMed:11041856}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008894	guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity
GO:0016787	hydrolase activity
GO:0017110	nucleoside-diphosphatase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0045134	uridine-diphosphatase activity

Biological Process

GO:0008152	metabolic process
GO:0032026	response to magnesium ion
GO:0051592	response to calcium ion

Cellular Component

GO:0000139	Golgi membrane
GO:0005615	extracellular space
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome