Version 5.4
Homo sapiens Gene: ENTPD6
Summary
InnateDB Gene IDBG-61152.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ENTPD6
Gene Name ectonucleoside triphosphate diphosphohydrolase 6 (putative)
Synonyms CD39L2; dJ738P15.3; IL-6SAG; IL6ST2; NTPDase-6
Species Homo sapiens
Ensembl Gene ENSG00000197586
Encoded Proteins
IDBP-61154
ectonucleoside triphosphate diphosphohydrolase 6 (putative)
IDBP-61156
ectonucleoside triphosphate diphosphohydrolase 6 (putative)
IDBP-61158
ectonucleoside triphosphate diphosphohydrolase 6 (putative)
IDBP-61164
ectonucleoside triphosphate diphosphohydrolase 6 (putative)
IDBP-369800
ectonucleoside triphosphate diphosphohydrolase 6 (putative)
IDBP-369801
ectonucleoside triphosphate diphosphohydrolase 6 (putative)
IDBP-369802
ectonucleoside triphosphate diphosphohydrolase 6 (putative)
IDBP-369805
ectonucleoside triphosphate diphosphohydrolase 6 (putative)
IDBP-369818
ectonucleoside triphosphate diphosphohydrolase 6 (putative)
IDBP-369819
ectonucleoside triphosphate diphosphohydrolase 6 (putative)
IDBP-369832
ectonucleoside triphosphate diphosphohydrolase 6 (putative)
IDBP-369833
ectonucleoside triphosphate diphosphohydrolase 6 (putative)
IDBP-369835
ectonucleoside triphosphate diphosphohydrolase 6 (putative)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary ENTPD6 is similar to E-type nucleotidases (NTPases). NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD6 contains 4 apyrase-conserved regions which is characteristic of NTPases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:25195693-25226729
Strand Forward strand
Band p11.21
Transcripts
ENST00000376666 ENSP00000365854
ENST00000376652 ENSP00000365840
ENST00000360031 ENSP00000353131
ENST00000354989 ENSP00000347084
ENST00000439162 ENSP00000408098
ENST00000433417 ENSP00000390095
ENST00000417467 ENSP00000395064
ENST00000427553 ENSP00000401573
ENST00000435520 ENSP00000398844
ENST00000418890 ENSP00000390511
ENST00000433259 ENSP00000401895
ENST00000425813 ENSP00000390646
ENST00000447877 ENSP00000406975
ENST00000471478
ENST00000485936
ENST00000481322
ENST00000463734
ENST00000490187
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008894 guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity
GO:0016787 hydrolase activity
GO:0017110 nucleoside-diphosphatase activity
GO:0017111 nucleoside-triphosphatase activity
GO:0045134 uridine-diphosphatase activity
Biological Process
GO:0008152 metabolic process
GO:0032026 response to magnesium ion
GO:0051592 response to calcium ion
Cellular Component
GO:0000139 Golgi membrane
GO:0005615 extracellular space
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033068
View Gene Order
ENSBTAG00000009881
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00240
Pyrimidine metabolism pathway
hsa00230
Purine metabolism pathway
INOH
INOH website
Purine nucleotides nucleosides metabolism pathway
INOH website
Pyrimidine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.500375
RefSeq NM_001114089 NM_001247 XM_005260878 XM_005260881 XM_005260882 XM_005260883 XM_005260885 XM_005260886 XM_006723665
HUGO
OMIM
CCDS CCDS13170 CCDS46586
HPRD 16013
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca