InnateDB Protein
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IDBP-61164.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ENTPD6
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Protein Name
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ectonucleoside triphosphate diphosphohydrolase 6 (putative)
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Synonyms
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CD39L2; dJ738P15.3; IL-6SAG; IL6ST2; NTPDase-6;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000347084
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InnateDB Gene
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IDBG-61152 (ENTPD6)
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Protein Structure
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Function |
Might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides. Hydrolyzes preferentially nucleoside 5'-diphosphates, nucleoside 5'-triphosphates are hydrolyzed only to a minor extent, there is no hydrolysis of nucleoside 5'-monophosphates. The order of activity with different substrates is GDP > IDP >> UDP = CDP >> ADP (By similarity). {ECO:0000250}.
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Subcellular Localization |
Golgi apparatus membrane; Single-pass type II membrane protein. Secreted. Note=But also occurs in a soluble extracellular form.
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Disease Associations |
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Tissue Specificity |
Expressed in most tissues, but predominantly in heart. {ECO:0000269PubMed:11041856}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000407
Nucleoside phosphatase GDA1/CD39
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PFAM |
PF01150
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O75354
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PhosphoSite |
PhosphoSite-O75354
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
955
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UniGene |
Hs.500375
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RefSeq |
NP_001107561
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HUGO |
HGNC:3368
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OMIM |
603160
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CCDS |
CCDS46586
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HPRD |
16013
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IMGT |
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EMBL |
AF039916
AL035252
AL834158
AY327581
BC025980
CH471133
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GenPept |
AAC39883
AAH25980
AAP92131
CAB41571
CAD38864
CAI22592
EAX10095
EAX10097
EAX10098
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