InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KCNIP3

Summary

InnateDB Protein

IDBP-61169.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNIP3

Protein Name

Kv channel interacting protein 3, calsenilin

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000295225

InnateDB Gene

IDBG-61167 (KCNIP3)

Protein Structure

UniProt Annotation

Function

Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity). {ECO:0000250}.Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and probably KCND3 trafficking to the cell surface.May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of beta-amyloid formation.

Subcellular Localization

Cytoplasm. Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Endoplasmic reticulum. Golgi apparatus. Nucleus. Note=Also membrane-bound, associated with the plasma membrane (By similarity). In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi. The sumoylated form is present only in the nucleus. {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in brain. Widely expressed at lower levels. Expression levels are elevated in brain cortex regions affected by Alzheimer disease. {ECO:0000269PubMed:14720210}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003714	transcription corepressor activity
GO:0005244	voltage-gated ion channel activity
GO:0005267	potassium channel activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0015459	potassium channel regulator activity
GO:0043565	sequence-specific DNA binding
GO:0044325	ion channel binding
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006886	intracellular protein transport
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0019233	sensory perception of pain
GO:0034765	regulation of ion transmembrane transport
GO:0043523	regulation of neuron apoptotic process
GO:0048265	response to pain
GO:0048266	behavioral response to pain
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005634	nucleus
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0032993	protein-DNA complex
GO:0043679	axon terminus