InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: OASL

Summary

InnateDB Protein

IDBP-61211.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OASL

Protein Name

2'-5'-oligoadenylate synthetase-like

Synonyms

OASLd; p59 OASL; p59-OASL; p59OASL; TRIP-14; TRIP14;

Species

Homo sapiens

Ensembl Protein

ENSP00000257570

InnateDB Gene

IDBG-61209 (OASL)

Protein Structure

UniProt Annotation

Function

Does not have 2'-5'-OAS activity, but can bind double- stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L. {ECO:0000269PubMed:18931074, ECO:0000269PubMed:20074559, ECO:0000269PubMed:9826176}.

Subcellular Localization

Isoform p56: Nucleus, nucleolus. Cytoplasm.Isoform p30: Cytoplasm.

Disease Associations

Tissue Specificity

Expressed in most tissues, with the highest levels in primary blood Leukocytes and other hematopoietic system tissues, colon, stomach and to some extent in testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0003725	double-stranded RNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016740	transferase activity
GO:0044822	poly(A) RNA binding
GO:0046966	thyroid hormone receptor binding

Biological Process

GO:0006955	immune response
GO:0008152	metabolic process
GO:0009615	response to virus
GO:0019221	cytokine-mediated signaling pathway
GO:0045071	negative regulation of viral genome replication
GO:0051607	defense response to virus
GO:0060333	interferon-gamma-mediated signaling pathway
GO:0060337	type I interferon signaling pathway

Cellular Component

GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000626 Ubiquitin-like
IPR006116 2-5-oligoadenylate synthetase, N-terminal
IPR018952 2\'-5\'-oligoadenylate synthetase 1, domain 2/C-terminal
IPR022617 Rad60/SUMO-like domain
IPR029071 Ubiquitin-related domain

PFAM

PF00240
PF14560
PF10421
PF11976

PRINTS

PIRSF

SMART

SM00213

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q15646