InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GAK

Summary

InnateDB Protein

IDBP-6128.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GAK

Protein Name

cyclin G associated kinase

Synonyms

DNAJ26; DNAJC26;

Species

Homo sapiens

Ensembl Protein

ENSP00000314499

InnateDB Gene

IDBG-6126 (GAK)

Protein Structure

UniProt Annotation

Function

Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin- coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1. {ECO:0000269PubMed:10625686}.

Subcellular Localization

Cytoplasm, perinuclear region {ECO:0000269PubMed:10625686}. Golgi apparatus, trans-Golgi network {ECO:0000269PubMed:10625686}. Cell junction, focal adhesion {ECO:0000305PubMed:10625686}. Note=Localizes to the perinuclear area and to the trans-Golgi network. Also seen on the plasma membrane, probably at focal adhesions.

Disease Associations

Tissue Specificity

Ubiquitous. Highest in testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	24 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0020037	heme binding

Biological Process

GO:0006118	electron transport
GO:0006468	protein phosphorylation
GO:0007029	endoplasmic reticulum organization
GO:0007030	Golgi organization
GO:0007049	cell cycle
GO:0009913	epidermal cell differentiation
GO:0035622	intrahepatic bile duct development
GO:0048468	cell development
GO:0048853	forebrain morphogenesis
GO:0061436	establishment of skin barrier
GO:0072318	clathrin coat disassembly
GO:0072583	clathrin-mediated endocytosis
GO:2000179	positive regulation of neural precursor cell proliferation

Cellular Component

GO:0005794	Golgi apparatus
GO:0005925	focal adhesion
GO:0016020	membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000008 C2 domain
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001623 DnaJ domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR014020 Tensin phosphatase, C2 domain
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR029021 Protein-tyrosine phosphatase-like
IPR029023 Tensin phosphatase, lipid phosphatase domain

PFAM

PF00168
PF00069
PF07714
PF00226
PF10409

PRINTS

PR00360
PR00109
PR00625

PIRSF

SMART

SM00239
SM00271
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt