Version 5.4
Homo sapiens Protein: MED12L
Summary
InnateDB Protein IDBP-61395.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MED12L
Protein Name mediator complex subunit 12-like
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000310760
InnateDB Gene IDBG-61393 (MED12L)
Protein Structure
UniProt Annotation
Function May be a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001104 RNA polymerase II transcription cofactor activity
GO:0008013 beta-catenin binding
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
Cellular Component
GO:0016592 mediator complex
Protein Structure and Domains
PDB ID
InterPro IPR019035 Mediator complex, subunit Med12
IPR021990 Mediator complex, subunit Med12, LCEWAV-domain
PFAM PF09497
PF12145
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86YW9
PhosphoSite PhosphoSite-Q86YW9
TrEMBL
UniProt Splice Variant
Entrez Gene 116931
UniGene Hs.666253
RefSeq
HUGO HGNC:16050
OMIM 611318
CCDS
HPRD 10278
IMGT
EMBL AB046855 AF090917 AF388364 AF388365 AF399708 AK022714 CH471052
GenPept AAF24035 AAL09579 AAL09580 AAO38813 BAB13461 BAB14198 EAW78800

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca