InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARAF

Summary

InnateDB Protein

IDBP-61506.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARAF

Protein Name

v-raf murine sarcoma 3611 viral oncogene homolog

Synonyms

A-RAF; ARAF1; PKS2; RAFA1;

Species

Homo sapiens

Ensembl Protein

ENSP00000366244

InnateDB Gene

IDBG-61504 (ARAF)

Protein Structure

UniProt Annotation

Function

Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. {ECO:0000269PubMed:22609986}.Isoform 2: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation. {ECO:0000269PubMed:22609986}.

Subcellular Localization

Disease Associations

Tissue Specificity

Predominantly in urogenital tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	73 [view]
Protein-Protein	71 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005057	receptor signaling protein activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046872	metal ion binding

Biological Process

GO:0006464	cellular protein modification process
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0032006	regulation of TOR signaling
GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0035556	intracellular signal transduction
GO:0043066	negative regulation of apoptotic process

Cellular Component

GO:0005575

cellular_component

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR003116 Raf-like Ras-binding
IPR011009 Protein kinase-like domain
IPR020454 Diacylglycerol/phorbol-ester binding
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR029071 Ubiquitin-related domain

PFAM

PF00069
PF07714
PF00130
PF02196

PRINTS

PR00109
PR00008

PIRSF

SMART

SM00109
SM00220
SM00455
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt