Version 5.4
Homo sapiens Protein: TMEM127
Summary
InnateDB Protein IDBP-61550.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMEM127
Protein Name transmembrane protein 127
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000258439
InnateDB Gene IDBG-61548 (TMEM127)
Protein Structure
UniProt Annotation
Function Controls cell proliferation acting as a negative regulator of TOR signaling pathway mediated by mTORC1. May act as a tumor suppressor. {ECO:0000269PubMed:20154675}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:20154675}; Multi-pass membrane protein {ECO:0000269PubMed:20154675}. Cytoplasm {ECO:0000269PubMed:20154675}. Note=Association of TMEM127 with the cell membrane is enhanced by inhibition of endocytosis. In the cytoplasm, it colocalizes with markers of early endosomal structures, Golgi apparatus and lysosomes.
Disease Associations Pheochromocytoma (PCC) [MIM:171300]: A catecholamine- producing tumor of chromaffin tissue of the adrenal medulla or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of epinephrine and norepinephrine, is hypertension, which may be persistent or intermittent. {ECO:0000269PubMed:20154675}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Tissue Specificity Widely expressed. {ECO:0000269PubMed:20154675}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0008285 negative regulation of cell proliferation
GO:0032007 negative regulation of TOR signaling
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75204
PhosphoSite PhosphoSite-O75204
TrEMBL C9J4H2
UniProt Splice Variant
Entrez Gene 55654
UniGene Hs.715688
RefSeq NP_060319
HUGO HGNC:26038
OMIM 613403
CCDS CCDS2018
HPRD 07917
IMGT
EMBL AC004020 AC012307 AC021188 AK000514 BC028575 BC039892 CH471207
GenPept AAC23494 AAH28575 AAH39892 AAY24224 BAA91220 EAW71376 EAW71377 EAW71378 EAW71379

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca