Version 5.4
Homo sapiens Gene: TMEM127
Summary
InnateDB Gene IDBG-61548.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMEM127
Gene Name transmembrane protein 127
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000135956
Encoded Proteins
IDBP-61550
transmembrane protein 127
IDBP-382812
transmembrane protein 127
IDBP-382816
transmembrane protein 127
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a transmembrane protein with 3 predicted transmembrane domains. The protein is associated with a subpopulation of vesicular organelles corresponding to early endosomal structures, with the Golgi, and with lysosomes, and may participate in protein trafficking between these structures. Mutations in this gene and several other genes cause pheochromocytomas. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:96248516-96265994
Strand Reverse strand
Band q11.2
Transcripts
ENST00000258439 ENSP00000258439
ENST00000432959 ENSP00000416660
ENST00000435268 ENSP00000411810
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0008285 negative regulation of cell proliferation
GO:0032007 negative regulation of TOR signaling
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034850
View Gene Order
ENSBTAG00000015667
Not yet available
Cross-References
SwissProt
TrEMBL C9J4H2
UniProt Splice Variant
Entrez Gene 55654
UniGene Hs.164303 Hs.715688
RefSeq NM_001193304 NM_017849
HUGO HGNC:26038
OMIM 613403
CCDS CCDS2018
HPRD 07917
IMGT
EMBL AC012307 AC021188
GenPept
RNA Seq Atlas 55654

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca