InnateDB Protein
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IDBP-61589.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CANX
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Protein Name
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calnexin
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Synonyms
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CNX; IP90; P90;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000247461
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InnateDB Gene
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IDBG-61587 (CANX)
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Protein Structure
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Function |
Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at the synapse.
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Subcellular Localization |
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. The palmitoylated form preferentially localizes to the perinuclear rough ER.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 125 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated |
Total |
125
[view]
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Protein-Protein |
124
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
10 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001580
Calreticulin/calnexin
IPR008985
Concanavalin A-like lectin/glucanases superfamily
IPR009033
Calreticulin/calnexin, P domain
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PFAM |
PF00262
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PRINTS |
PR00626
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P27824
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PhosphoSite |
PhosphoSite-P27824
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TrEMBL |
D6RHJ3
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UniProt Splice Variant |
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Entrez Gene |
821
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UniGene |
Hs.567968
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RefSeq |
NP_001737
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HUGO |
HGNC:1473
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OMIM |
114217
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CCDS |
CCDS4447
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HPRD |
00252
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IMGT |
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EMBL |
AC113426
AC136604
AJ271880
AK294702
AK304420
AK312334
BC003552
BC042843
CH471165
L10284
L18887
M94859
M98452
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GenPept |
AAA21013
AAA21749
AAA35696
AAA36125
AAH03552
AAH42843
BAG35255
BAG57859
BAG65250
CAB72137
EAW53802
EAW53803
EAW53805
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