Version 5.4
Homo sapiens Protein: SKA2
Summary
InnateDB Protein IDBP-61596.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SKA2
Protein Name spindle and kinetochore associated complex subunit 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000333433
InnateDB Gene IDBG-61594 (SKA2)
Protein Structure
UniProt Annotation
Function Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it is required for SKA1 localization. {ECO:0000269PubMed:17093495, ECO:0000269PubMed:19289083}.
Subcellular Localization Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner. Localizes to both the mitotic spindle and kinetochore-associated proteins.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008017 microtubule binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
GO:0031110 regulation of microtubule polymerization or depolymerization
GO:0051301 cell division
Cellular Component
GO:0000940 condensed chromosome outer kinetochore
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005876 spindle microtubule
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WVK7
PhosphoSite PhosphoSite-Q8WVK7
TrEMBL J3QL03
UniProt Splice Variant
Entrez Gene 348235
UniGene Hs.619211
RefSeq NP_872426
HUGO HGNC:28006
OMIM
CCDS CCDS45747
HPRD 13306
IMGT
EMBL AC099850 AK056473 BC017873 BC106003 BI835364 CH471109
GenPept AAH17873 AAI06004 BAG51725 EAW94420

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca