InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SMG8

Summary

InnateDB Protein

IDBP-61622.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMG8

Protein Name

smg-8 homolog, nonsense mediated mRNA decay factor (C. elegans)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000300917

InnateDB Gene

IDBG-61620 (SMG8)

Protein Structure

UniProt Annotation

Function

Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity. {ECO:0000269PubMed:19417104}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0045859	regulation of protein kinase activity