InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BMI1

Summary

InnateDB Protein

IDBP-61694.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BMI1

Protein Name

BMI1 polycomb ring finger oncogene

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000365851

InnateDB Gene

IDBG-61688 (BMI1)

Protein Structure

UniProt Annotation

Function

Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2. {ECO:0000269PubMed:16359901, ECO:0000269PubMed:16714294, ECO:0000269PubMed:16882984}.

Subcellular Localization

Nucleus. Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 413 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	413 [view]
Protein-Protein	411 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding
GO:0071535	RING-like zinc finger domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0007379	segment specification
GO:0010468	regulation of gene expression
GO:0016568	chromatin modification
GO:0030097	hemopoiesis
GO:0048146	positive regulation of fibroblast proliferation
GO:0051443	positive regulation of ubiquitin-protein transferase activity