Version 5.4
Homo sapiens Gene: BMI1
Summary
InnateDB Gene IDBG-61688.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BMI1
Gene Name BMI1 polycomb ring finger oncogene
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000168283
Encoded Proteins
IDBP-61694
BMI1 polycomb ring finger oncogene
IDBP-369198
BMI1 polycomb ring finger oncogene
IDBP-369206
BMI1 polycomb ring finger oncogene
IDBP-369212
BMI1 polycomb ring finger oncogene
IDBP-369222
BMI1 polycomb ring finger oncogene
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This locus represents naturally occurring read-through transcription between the neighboring COMM domain-containing protein 3 and polycomb complex protein BMI-1 genes on chromosome 10. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:22321211-22331484
Strand Forward strand
Band p12.2
Transcripts
ENST00000376663 ENSP00000365851
ENST00000417470 ENSP00000398759
ENST00000442508 ENSP00000397912
ENST00000456675
ENST00000416820 ENSP00000399220
ENST00000443519 ENSP00000390768
ENST00000496174
ENST00000490311
ENST00000602523
ENST00000602358
ENST00000602524
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 413 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 413 [view]
Protein-Protein 411 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
GO:0071535 RING-like zinc finger domain binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0007379 segment specification
GO:0010468 regulation of gene expression
GO:0016568 chromatin modification
GO:0030097 hemopoiesis
GO:0048146 positive regulation of fibroblast proliferation
GO:0051443 positive regulation of ubiquitin-protein transferase activity
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0031519 PcG protein complex
GO:0035102 PRC1 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026739
View Gene Order
ENSBTAG00000015584
Not yet available
Pathways
NETPATH
REACTOME
REACT_120956
Cellular responses to stress pathway
REACT_169274
Cellular Senescence pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
KEGG
INOH
PID NCI
myc_activpathway
Validated targets of C-MYC transcriptional activation
Cross-References
SwissProt
TrEMBL Q5T8Z2
UniProt Splice Variant
Entrez Gene 648
UniGene Hs.380403
RefSeq NM_005180 NM_001204062
HUGO HGNC:1066
OMIM 164831
CCDS CCDS7138 CCDS59213
HPRD 01277
IMGT
EMBL AL158211
GenPept
RNA Seq Atlas 648

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca